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KMID : 0613820050150020261
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Journal of Life Science
2005 Volume.15 No. 2 p.261 ~ p.266
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Investigation of Conserved Genes in Microorganism
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Lee Dong-Geun
Lee Jae-Hwa
Lee Sang-Hyun
Ha Bae-Jin
Sim Doo-Hee
Park Eun-Kyung
Kim Jin-Uk
Lee Hua-Yue
Nam Chun-Suk
Kim Nam-Young
Lee Eo-Jin
Ha Jong-Myuong
Back Jin-Wook
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Abstract
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To figure out conserved genes in 66 microbial species and measuring the degree of conservation, analyses based on COG (Clusters of Orthologous Groups of proteins) algorithm were applied. Sixty-six microbial genomes, including three eukaryotes, hold 63 conserved orthologs in common. The majority (82.5%) of the conserved genes was related to translation, meaning the importance of protein in living creatures. Ribosomal protein S12 (COG0048) and L14 (COG0093) were more conserved genes than others from the distance value analysis. Phylogenetically related microbes grouped in genome analysis by average and standard deviation of 63 conserved genes. The 63 conserved genes, found in this research, would be useful in basic research and applied ones such as antibiotic development.
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KEYWORD
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